Just like you say, there are many factors and different approaches will work differently in different rooms to an extent as well. Because I've procrastinated a lot I run a dual opposed 15" with three single 18"s (I have the 18" drivers for a dual opposed build too). Not an issue but they have similar response characteristics (as measured at data-bass.com). I've also run mismatched subs in other rooms at times without particular issue, with a bit wider variation in response. You will be limited by the less capable sub, too.
Since shadyj says they should work together well I'd take his word for it, you might check shadyj's reviews:
At last! It's here! Our review of Monoprice's monster subwoofer, the Monolith 15" THX Ultra! This 130 lb. beast might look like it's all muscle, but there's at least as much brains as there is brawn.
www.audioholics.com
In this review, we look at two high-powered but affordable Monoprice subwoofers, the 10" THX Select and 12" THX Ultra. Continue reading to find out if your home theater room can handle these beasts.
www.audioholics.com