Having different subs can work, but not all the time, and care has to be taken in selecting the subs. The problem is that if you pair a weak sub with a powerful sub, at higher drive levels the weak sub may run into heavy distortion which degrades the overall sound, so it would have been better not to add the weak sub at all. You need to ensure that the weak sub is strictly limited so that it doesn't run into heavy distortion at high drive levels. The good news for you is that the Monolith subs do just that. The 12"s can not be pushed into heavy distortion, and that is mandated by their THX certification. If you drive the full throttle, they just stop getting louder. So yes, you can mix the Monolith 12" and 15" subs, and it will work just fine.