My HT/stereo setup is a mess for an audiophile. I have my living room open to my dining room. The TV is in a stand in the corner, and the stand is at an angle so the tv can be viewed from both rooms. The front speakers are bookshelves on a shelf above the TV. The center is on a shelf below the tv. The sub is on the left of the tv, in the corner that has been made between the stand and the wall. The rears are on 5 foot high stands, one at the back of the living room and the other somewhat in the dining room pointing into the living room. The layout is the best it can be with the layout, windows, doors, open area, and SAF.
As for sound, the bass works very well in the living room but the dining room doesn't get much. I've always considered to put another sub in the dining room to help get some bass in there.
later,