Coronavirus

[Swerd]

I also have questions.

1. What would account for the uninfected seemingly becoming "smarter" in the quarantine period?

2. What would account for both groups appearing to decline significantly after 90 days?

No, you're not reading it wrong. Both your questions reflect the unreliability of unblinded self-assessments.

Your first question suggests the number of people in the study group was too small. Is that a real difference, or would these apparent differences go away in a larger group?

Your second question about the significant decline in both groups after 90 days, suggests how big a factor motivation played in these self-assessments. After 90 days it might have been too boring to perform those same tests again.

 

[Swerd]

@mtrot
You read this graph more carefully than I did. After I saw the Y axis label "Baseline Corrected Global Composite Cognitive Score (SDU)" I shrugged and gave up looking at it more closely. What does that title mean? What does SDU stand for?

It looks to me like the Y axis is a ratio of some kind with positive and negative values, with zero in the middle. Are these ratios, corrected (normalized) to something? Are differences between ratios of zero and +0.5 to +1.5 large or small? Any thing that compares corrected ratios has a significant error built into it. If you show scores with less correction, without a multiplication or division step in it, these errors will be smaller.

 

[davidscott]

In what way did you feel that? Covid shot makes my arm a bit stiff, not the flue. No running nose are anything.

The senior flu shot made my arm hurt more than the covid. I believe the overall body aches were due the covid shot as that has happened to me in the past. The difference is that I took alieve this time which I never did in the past. Still felt bad but not horrible. Anyway 2 days later all good.

 

[mtrycrafts]

The senior flu shot made my arm hurt more than the covid. I believe the overall body aches were due the covid shot as that has happened to me in the past. The difference is that I took alieve this time which I never did in the past. Still felt bad but not horrible. Anyway 2 days later all good.

My last year's combo shot was 180 from yours. Flu was nothing, unless it wasn't a senior dose that it should have been. A bit of sore arm for Covid, same with the shot 6 month ago.
Yes, two days is nothing but a memory. Better than the alternative.

 

[davidscott]

My last year's combo shot was 180 from yours. Flu was nothing, unless it wasn't a senior dose that it should have been. A bit of sore arm for Covid, same with the shot 6 month ago.
Yes, two days is nothing but a memory. Better than the alternative.

Absolutely better than the alternative. Glad you have less reactions than I do. Tomorrow, I get the RSV shot. Dont expect any reaction.

 

[cpp]

Absolutely better than the alternative. Glad you have less reactions than I do. Tomorrow, I get the RSV shot. Dont expect any reaction.

I get the RSV late next week as well. And what I've heard, its the shot that can really fatigue you. I guess we shall see.

 

[Mr._Clark]

CNN has an article listing COVID wastewater levels for each state:

https://www.cnn.com/2024/09/29/health/covid-wastewater-testing-map-dg/index.html

 

[mtrot]

I realize this is a small study, but many of the "young, healthy, seronegative volunteers" had cognitive problems after they were given the COVID virus.

View attachment 69697

>>>Patient-reported outcomes and cross-sectional evidence show an association between COVID-19 and persistent cognitive problems. The causal basis, longevity and domain specificity of this association is unclear due to population variability in baseline cognitive abilities, vulnerabilities, virus variants, vaccination status and treatment. . . . These results support larger cross sectional findings indicating that mild Wildtype SARS-CoV-2 infection can be followed by small changes in cognition and memory that persist for at least a year. The mechanistic basis and clinical implications of these small changes remain unclear. . . .

We found that volunteers who exhibited sustained viral load after inoculation with SARS-CoV-2 performed worse on a measure of global cognition, than volunteers who did not exhibit sustained viral load. This deficit persisted up to a year after inoculation. <<<

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00421-8/fulltext

Getting back to this study, I remain skeptical. Can anyone tell me if a sustained diminution of cognitive function has been suggested or documented after infection with any other virus, i.e., influenza, RSV, rhinovirus, or even other coronaviruses? Is a sustained cognitive diminution a known effect? Because, if so, and considering the number of times the average person becomes infected with viruses during their life, wouldn't we all be numbskulls by the age of 50 or 60? Or, could the covid virus be uniquely able to produce this effect? I have no idea, just wondering.

 

[highfigh]

Getting back to this study, I remain skeptical. Can anyone tell me if a sustained diminution of cognitive function has been suggested or documented after infection with any other virus, i.e., influenza, RSV, rhinovirus, or even other coronaviruses? Is a sustained cognitive diminution a known effect? Because, if so, and considering the number of times the average person becomes infected with viruses during their life, wouldn't we all be numbskulls by the age of 50 or 60? Or, could the covid virus be uniquely able to produce this effect? I have no idea, just wondering.

A former neighbor who works in health care told me about his problems after COVID, which included the feeling that he was standing on foam rubber, 'brain fog', fatigue and coughing after recovery. He works for Ascention and they decided that since he had been a police officer and had served in the military, he would be able to handle moving the many patients who died 'from COVID' into refrigerated trailers. Great.

Not results from a study, but still disturbing.

 

[Swerd]

Getting back to this study, I remain skeptical. Can anyone tell me if a sustained diminution of cognitive function has been suggested or documented after infection with any other virus, i.e., influenza, RSV, rhinovirus, or even other coronaviruses?

Go back to the Lancet paper and carefully read the Introduction and Discussion sections. Look up all the papers these authors cite, (Especially see references 1-12. Use the PubMed links.)

Read & understand these papers as well as you can. They should answer most of your questions. They may not satisfy you, but it shows that the authors know about them and think they are valid background for their own study.

In brief, they say that many previous clinical observations of Covid-19 patients suggest that cognitive impairment may be a problem. Much more research is needed before this can be though of as a likely consequence of Covid-19 infection.

Is a sustained cognitive diminution a known effect? Because, if so, and considering the number of times the average person becomes infected with viruses during their life, wouldn't we all be numbskulls by the age of 50 or 60? Or, could the covid virus be uniquely able to produce this effect? I have no idea, just wondering.

The authors wondered too. That's why they did the study.