R

RedCharles

Audioholic

This may be serious. The videos I saw on twitter were disturbing. The hospital(s) appear to be overwhelmed.

Wuhan is larger than NYC. And it's not the only city on lockdown. As of 5 hours ago, there are 23 million under quarantine.
 
Last edited:
H

Hetfield

Audioholic General
I haven't been following this as closely as I should. What exactly is going on? Is this a brand be disease because they have a name for it already? Seems the identified it quickly. Sound dangerous either way, scary as hell.
 
davidscott

davidscott

Audioholic Field Marshall
Thanks for the heads up. I will have to keep an eye on this...
 
TLS Guy

TLS Guy

Audioholic Slumlord
This is a statement issued today by some of the most eminent infectious disease specialist. Of particular note Dr Anthony Fauci is one of the authors.

This is technical, but very well written. I think most of you will get the gist of it, and I will do my best to clarify what you may not understand.

From a personal perspective I think the initial world response to outbreak of novel infectious disease, needs to be quicker and much more robust.

Here is the best information I can find to date.


Viewpoint
January 23, 2020
Coronavirus Infections—More Than Just the Common Cold
Catharine I. Paules, MD1; Hilary D. Marston, MD, MPH2; Anthony S. Fauci, MD2
Author Affiliations Article Information
JAMA. Published online January 23, 2020. doi:10.1001/jama.2020.0757


Human coronaviruses (HCoVs) have long been considered inconsequential pathogens, causing the “common cold” in otherwise healthy people. However, in the 21st century, 2 highly pathogenic HCoVs—severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV)—emerged from animal reservoirs to cause global epidemics with alarming morbidity and mortality. In December 2019, yet another pathogenic HCoV, 2019 novel coronavirus (2019-nCoV), was recognized in Wuhan, China, and has caused serious illness and death. The ultimate scope and effect of this outbreak is unclear at present as the situation is rapidly evolving.
Coronaviruses are large, enveloped, positive-strand RNA viruses that can be divided into 4 genera: alpha, beta, delta, and gamma, of which alpha and beta CoVs are known to infect humans.1 Four HCoVs (HCoV 229E, NL63, OC43, and HKU1) are endemic globally and account for 10% to 30% of upper respiratory tract infections in adults. Coronaviruses are ecologically diverse with the greatest variety seen in bats, suggesting that they are the reservoirs for many of these viruses.2 Peridomestic mammals may serve as intermediate hosts, facilitating recombination and mutation events with expansion of genetic diversity. The surface spike (S) glycoprotein is critical for binding of host cell receptors and is believed to represent a key determinant of host range restriction.1
Until recently, HCoVs received relatively little attention due to their mild phenotypes in humans. This changed in 2002, when cases of severe atypical pneumonia were described in Guangdong Province, China, causing worldwide concern as disease spread via international travel to more than 2 dozen countries.2 The new disease became known as severe acute respiratory syndrome (SARS), and a beta-HCoV, named SARS-CoV, was identified as the causative agent. Because early cases shared a history of human-animal contact at live game markets, zoonotic transmission of the virus was strongly suspected.3 Palm civets and raccoon dogs were initially thought to be the animal reservoir(s); however, as more viral sequence data became available, consensus emerged that bats were the natural hosts.
Common symptoms of SARS included fever, cough, dyspnea, and occasionally watery diarrhea.2 Of infected patients, 20% to 30% required mechanical ventilation and 10% died, with higher fatality rates in older patients and those with medical comorbidities. Human-to-human transmission was documented, mostly in health care settings. This nosocomial spread may be explained by basic virology: the predominant human receptor for the SARS S glycoprotein, human angiotensin-converting enzyme 2 (ACE2), is found primarily in the lower respiratory tract, rather than in the upper airway. Receptor distribution may account for both the dearth of upper respiratory tract symptoms and the finding that peak viral shedding occurred late (≈10 days) in illness when individuals were already hospitalized. SARS care often necessitated aerosol-generating procedures such as intubation, which also may have contributed to the prominent nosocomial spread.
Several important transmission events did occur in the community, such as the well-characterized mini-outbreak in the Hotel Metropole in Hong Kong from where infected patrons traveled and spread SARS internationally. Another outbreak occurred at the Amoy Gardens housing complex where more than 300 residents were infected, providing evidence that airborne transmission of SARS-CoV can sometimes occur.4 Nearly 20 years later, the factors associated with transmission of SARS-CoV, ranging from self-limited animal-to-human transmission to human superspreader events, remain poorly understood.
Ultimately, classic public health measures brought the SARS pandemic to an end, but not before 8098 individuals were infected and 774 died.2 The pandemic cost the global economy an estimated $30 billion to $100 billion.1 SARS-CoV demonstrated that animal CoVs could jump the species barrier, thereby expanding perception of pandemic threats.
In 2012, another highly pathogenic beta-CoV made the species jump when Middle East respiratory syndrome (MERS) was recognized and MERS-CoV was identified in the sputum of a Saudi man who died from respiratory failure.3 Unlike SARS-CoV, which rapidly spread across the globe and was contained and eliminated in relatively short order, MERS has smoldered, characterized by sporadic zoonotic transmission and limited chains of human spread. MERS-CoV has not yet sustained community spread; instead, it has caused explosive nosocomial transmission events, in some cases linked to a single superspreader, which are devastating for health care systems. According to the World Health Organization (WHO), as of November 2019, MERS-CoV has caused a total of 2494 cases and 858 deaths, the majority in Saudi Arabia. The natural reservoir of MERS-CoV is presumed to be bats, yet human transmission events have primarily been attributed to an intermediate host, the dromedary camel.
MERS shares many clinical features with SARS such as severe atypical pneumonia, yet key differences are evident. Patients with MERS have prominent gastrointestinal symptoms and often acute kidney failure, likely explained by the binding of the MERS-CoV S glycoprotein to dipeptidyl peptidase 4 (DPP4), which is present in the lower airway as well as the gastrointestinal tract and kidney.3 MERS necessitates mechanical ventilation in 50% to 89% of patients and has a case fatality rate of 36%.2
While MERS has not caused the international panic seen with SARS, the emergence of this second, highly pathogenic zoonotic HCoV illustrates the threat posed by this viral family. In 2017, the WHO placed SARS-CoV and MERS-CoV on its Priority Pathogen list, hoping to galvanize research and the development of countermeasures against CoVs.
The action of the WHO proved prescient. On December 31, 2019, Chinese authorities reported a cluster of pneumonia cases in Wuhan, China, most of which included patients who reported exposure to a large seafood market selling many species of live animals. Emergence of another pathogenic zoonotic HCoV was suspected, and by January 10, 2020, researchers from the Shanghai Public Health Clinical Center & School of Public Health and their collaborators released a full genomic sequence of 2019-nCoV to public databases, exemplifying prompt data sharing in outbreak response. Preliminary analyses indicate that 2019-nCoV has some amino acid homology to SARS-CoV and may be able to use ACE2 as a receptor. This has important implications for predicting pandemic potential moving forward. The situation with 2019-nCoV is evolving rapidly, with the case count currently growing into the hundreds. Human-to-human transmission of 2019-nCoV occurs, as evidenced by the infection of 15 health care practitioners in a Wuhan hospital. The extent, if any, to which such transmission might lead to a sustained epidemic remains an open and critical question. So far, it appears that the fatality rate of 2019-nCoV is lower than that of SARS-CoV and MERS-CoV; however, the ultimate scope and effects of the outbreak remain to be seen.
Drawing on experience from prior zoonotic CoV outbreaks, public health authorities have initiated preparedness and response activities. Wuhan leaders closed and disinfected the first identified market. The United States and several other countries have initiated entry screening of passengers from Wuhan at major ports of entry. Health practitioners in other Chinese cities, Thailand, Japan, and South Korea promptly identified travel-related cases, isolating individuals for further care. The first travel-related case in the United States occurred on January 21 in a young Chinese man who had visited Wuhan.
Additionally, biomedical researchers are initiating countermeasure development for 2019-nCoV using SARS-CoV and MERS-CoV as prototypes. For example, platform diagnostic modalities are being rapidly adapted to include 2019-nCoV, allowing early recognition and isolation of cases. Broad-spectrum antivirals, such as remdesivir, an RNA polymerase inhibitor, as well as lopinavir/ritonavir and interferon beta have shown promise against MERS-CoV in animal models and are being assessed for activity against 2019-nCoV.5 Vaccines, which have adapted approaches used for SARS-CoV or MERS-CoV, are also being pursued. For example, scientists at the National Institute of Allergy and Infectious Diseases Vaccine Research Center have used nucleic acid vaccine platform approaches.6 During SARS, researchers moved from obtaining the genomic sequence of SARS-CoV to a phase 1 clinical trial of a DNA vaccine in 20 months and have since compressed that timeline to 3.25 months for other viral diseases. For 2019-nCoV, they hope to move even faster, using messenger RNA (mRNA) vaccine technology. Other researchers are similarly poised to construct viral vectors and subunit vaccines.
While the trajectory of this outbreak is impossible to predict, effective response requires prompt action from the standpoint of classic public health strategies to the timely development and implementation of effective countermeasures. The emergence of yet another outbreak of human disease caused by a pathogen from a viral family formerly thought to be relatively benign underscores the perpetual challenge of emerging infectious diseases and the importance of sustained preparedness.

Back to top
Article Information
Corresponding Author: Anthony S. Fauci, MD, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, 31 Center Dr, MSC 2520, Bldg 31, Room 7A-03, Bethesda, MD 20892-2520 (afauci@niaid.nih.gov).
 
j_garcia

j_garcia

Audioholic Jedi
Our company deals a lot with China. We received notification last week that travel to China was restricted and this week that NO travel is permitted to China currently unless approved. I just came back from Taiwan a few weeks ago and there were already notices there that anyone with flu like symptoms should report it to authorities and seek medical attention as a precaution. So while reports are only recently coming up in the media here, it was already going on.
 
GO-NAD!

GO-NAD!

Audioholic Ninja
I'm no fan of totalitarian governments, but one advantage China has is, when they say an entire city is quarantined, they can enforce it.
 
Swerd

Swerd

Audioholic Spartan
I'm glad to see the Chinese authorities react sooner to this new outbreak than they did in 2002-03 with the SARS virus. SARS was eventually contained by quarantining infected people and limiting travel of people from areas of infection, but it spread rapidly before those actions were taken.

I saw this comparison of the new coronavirus to some other recent viral outbreaks. It was in today's Washington Post. Obviously, the new coronavirus info is early and numbers can and will change.
1579883512740.png

The take home that I see:
Measles is far more widespread and dangerous than any of these other diseases. And it's easily prevented with a vaccine.
 
Alex2507

Alex2507

Audioholic Slumlord
Does that Coronavirus make it burn when you pee?

Asking for a friend.
 
Swerd

Swerd

Audioholic Spartan
Does that Coronavirus make it burn when you pee?

Asking for a friend.
Of course it does. Tell your friend that a burning sensation as you pee is one of the last symptoms before penile organ failure. In a few days it will fall off.
 
Trell

Trell

Audioholic Chief
Of course it does. Tell your friend that a burning sensation as you pee is one of the last symptoms before penile organ failure. In a few days it will fall off.
That should cure any priapism, though.
 
John Parks

John Parks

Audioholic General
That's why I never drink the stuff. I mean, if you need to add a lime to make your beer taste better...
1579890535896.png


We are talking about the same thing, no?
 
mtrycrafts

mtrycrafts

Audioholic Slumlord
...
From a personal perspective I think the initial world response to outbreak of novel infectious disease, needs to be quicker and much more robust.
...
Absolutely right. With modern mass travel rapidly anyplace on the planet, this can spread before detection as many viruses takes a while to show an effect on a person.
 
R

RedCharles

Audioholic
There's no panic yet. Home Depot and Lowe's were not cleared out of masks, gloves or goggles. Although amazon is sold out of surgical masks, and large 3m full facemasks. Bunny suits are not sold out yet.

When I bought 100 cans of food no one looked at me any different.

I'm taking steps now, to get ready to hunker down. I've spent about 400 bucks so far, and probably spend more if the news keeps getting worse. I will be avoiding human contact as much as possible for the foreseeable future. I am extremely worried that this is a once in a century event; no one has the practical experience to size up the situation, and therefore I am fixated on the worst case.

My Dad was diagnosed with colon cancer yesterday, but I'm more fixated on coronavirus. Perhaps I am overreacting. Being mental. Perhaps everything will be ok. And in that case, I will have quite the stockpile of canned food and all the PPE I need to paint a car. Lol.

The radio is still going on about impeachment and Antonio Brown. Most people aren't scared yet.

There's a video on drudge of a hospital hallway with three bodies on the floor, faces covered by blankets, and everyone in the hall are simply looking on as if three dead bodies in a crowded hospital hallway was nothing to see.

With 45 million people under quarantine, I believe there may be millions infected, and tens of thousands dead. China's response to the disease is too strong for just 26 dead.

And with a possible two week incubation period, it may already be in every corner of the US.

The zero patient was early December, and it took a month and half for it to get out of control. Obviously we are not packed in like sardines in the West, so it may take longer for STHTF.

Regardless, I have kids, and I determined that we will live through this. I really do hope I am wildly wrong about the seriousness of the situation.
 
M

Midwesthonky

Audioholic Chief
From a personal perspective I think the initial world response to outbreak of novel infectious disease, needs to be quicker and much more robust.
Unfortunately, the global response could have been even faster if Chinese authorities hadn't tried to hide it from everyone including jailing reporters who first started to report on it. At least it is a faster response than in the past, but still the failures on the local level to quash reporting resulted in it getting out to several other countries. With global trade and transportation so quick, the human race will face issues with such diseases often.

As Davante Adams of the Green Bay Packers said when discussing the flu in the locker room: "Wash your hands and wash your butts."
 
TLS Guy

TLS Guy

Audioholic Slumlord
63 cases in the US under investigation with specimens sent to the CDC. Two of these cases are in Minnesota. The UK is now trying to trace 2000 individuals of concern. The UK had an emergency Cobra meeting this morning. There are believed to be 6 cases in Scotland and one in Belfast Norther Ireland. France is believed to have a confirmed case.
 

Latest posts


newsletter
  • RBHsound.com
  • BlueJeansCable.com
  • SVS Sound Subwoofers
  • Experience the Martin Logan Montis
Top