Here's an article about a person with a compromised immune system who was unable to clear the COVID virus during a long infection. The virus kept mutating and avoiding his immune system.
>>>A new report by Dutch scientists revealed a very peculiar case: On Feb. 2022, a 72-year-old man with a compromised immune system was admitted to Amsterdam University Medical Center with a
COVID-19 infection. The virus in his body proceeded to evolve over the course of 613 days, leading to a highly mutated variant that ultimately killed him.
According to the study, the man, whose identity was not disclosed, suffered from a blood disorder. Despite receiving multiple doses of the SARS-CoV-2 vaccine, his compromised immune system made him unable to generate a detectable antibody response, allowing the virus to continue to evolve into a "novel immune-evasive variant" that had mutated over 50 times.<<<
Through the 613 days of infection, the virus evolved into a "novel immune-evasive variant" that had mutated over 50 times.
scrippsnews.com