jcunwired,
I have the R300s roughly 7 feet up on a wall and mounted via a pair of Pinpoint AM-40. The R300s are rear ported, but I have not had a bass issue with the speakers tilted as far forward/down as possible.
I inverted the speaker to get the uni-drivers closer to my ears, and I thought it made a huge improvement in sound quality. Amazing how a foot can make such a large difference in sound.
To keep the speaker from tipping forward and/or sliding out of the mount, I utilized zip ties thru the secondary speaker plugs to make things more secure. I anchored a small hook into the support beam and attached the ties to the hook. The hook and zip ties don't handle more than a few pounds of load so they can be very small and are not noticeable unless you get right up to the speaker. I am 6'2" and I have to stand on a chair and look behind the speaker to see the ties.
On a side note: I would not use the AM-40 tilted forward with a decent sized speaker. The reason I secured everything is due to finding one speaker on the edge of falling after installing it a few hours earlier. The 50lb load limit might be possible if you add something to help secure the speaker from sliding.
The only issue I have had with the inverted R300s is that my wife asked if I could rotate the KEF emblem so it's not upside down.