Depends on what you're listening to, and at what level. Some guys use two towers 4' in from both walls, and sit 5' back from them. Acoustics won't affect him as much as the guy with 4 satellites in the corners, a center and subwoofer. If you're in a basement with block walls and concrete floors, you'd best stay away from horn loaded speakers, then spend your cash on carpeting, wall treatments, etc... I'd say it varies between 30-40% on the room, 30-40% on the speakers, and the rest on amp/preamp/eq/tweaking/quality of recorded material.