Properly controlled tests do not indicate audible differences - people can not discern biwired from non-biwired.
Granted, I've seen only a little actual data, but I've never seen a biwiring proponent offer the results of a properly controlled listening test to support their claim. They seem to rely exclusively on anecdotal reports.
I've run the tests myself. I arrived at the same conclusion that every other blind test found and that is that biwiring does not result in changes in audible sound. Science has categorically proven biwiring to be a meritless technique.
I spent 40 years as an audiophile and I was affected by placebo effect just like every other other audiophile. I heard what I thought I should hear or what I wanted to hear. It happens to everyone. There aren't any golden ears, just placebo effect. I got over it one day when I bought a thick, expensive power cord and couldn't hear an audible difference. That started a whole string of blind tests which, in the end, cured me of audiophilia. Now I listen to music instead of equipment. Most of my listening is done with a digital music server playing 320khz MP3's. That would get an audiophile to turn up his nose but the music performances are just as good as they always were. Non audiophiles who hear my system marvel at how good it sounds. It is all just a matter of perspective.
The astounding thing to me is that audiophiles refuse to understand or accept what science tells them about their techiques, their equipment or the way their hearing and brains function. A whole industry is built on a rejection of the placebo effect. It's really amazing to me.
I've trained myself well enough that I can now listen around the placebo effect much of the time. When things aren't audible, I don't hear them very often. I generally check things with a blind test but, overall, I've learned to overcome and manage the placebo effect. It isn't hard to do. Conduct 40 or 50 blind listening tests and you'll see what I mean. When I talk to an audiophile and debate the audibility of things like biwiring or digital cables or power cords, the response I always get is that something is defective with my hearing. The audiophile can hear better than I can. I can beleive what I like, he believes his ears. It is the response I get every time. I used to respond that way myself. Unfortunately it isn't a useful or accurate response.
An entire industry is built on people hearing what they want to hear rather than what they really hear when nothing subjective is included in the hearing. It really is amazing. It has been going on for decades. Sorry for the rant.