I must be nuts replying to a biwire question, but here goes anyway

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The best explanation I've heard as to why anyone might want to biwire is that the large voice coil/magnet assembly of a woofer generates a reverse voltage as the woofer moves back and forth, called "back EMF". The tweeter also generates back EMF, but it has much less energy to it than the woofer's back EMF.
If there is a single speaker cable, the woofer's back EMF can interfere with the weaker treble information. Whether this is audible has never been shown.
With biwiring, one speaker cable carries the bass to the woofer, and the other carries the treble to the tweeter. Any back EMF from the woofer is only on the woofer cable and is physically separated from the signal to the tweeter. If all this is true and is actually audible (people do love to argue this, but I've never seen or heard a convincing demonstration) then it makes sense that the two cables NOT be bundled together. The back EMF in a wire has its own electromagnetic field that can interfere with another wire if they are close enough.
If you must biwire, separate the two cables by about 4-6" to minimize any induced interference. Using biwire cable where four conductors are closely bundled together, may look nicer, but cannot prevent this induced interference.