Coronavirus

[TLS Guy]

This is Chris Kane, President of AudioControl who was infected by the same person I was. This drug Remdesvir saved his life. Hopefully this can be one of many drugs to help stop virus replication in the body to give COVID-19 patients a fighting chance.

Coronavirus in Washington state: Patient says Ebola drug saved his life

A COVID-19 infected Washington state man's life was saved thanks to the Ebola drug remdesvir.

nypost.com

Yes, I think that Remidisvir is the most promising drug to try. It was developed to fight Ebola, also a corona virus. It failed. However it has shown activity against MERS and SARS, also Corona viruses.

The Italians seem to think it is helpful is Covid 19. I do think this drug is the first one to look at rather then the toxic Plaquenil/Azithromycin combo.

The problem is that the drug is in short supply. It is a drug produced by Gilead Sciences. They are trying to increase production.

 

[Swerd]

Since it's a virus not a bacteria, I'm wondering if the virus has characteristics of bacteria?

Are you referring to my previous posts (below) about antibiotic drugs and bacteria that acquire resistance to them?

As with any antibiotic, the more you use it, the more bacteria get exposed to it. And with more exposure, the more likely bacteria will develop resistance to it. That's how multi-drug resistant microrganisms developed – over use.

That antibiotic, azithromycin, specifically inhibits protein synthesis in a wide range of bacteria, but has no known effect on eucaryotic cells.

If yes, I hope this answers your question:

At the simplest level, the cell machinery for protein synthesis (ribosomes) in eucaryotic cells (any cell with a nucleus separated from the cytoplasm) is different from that of bacteria (procaryotic cells, without a separate nucleus). So different, that a drug that inhibits protein synthesis in bacteria does not work in eucaryotic cells. That's why azithromycin works against infectious bacteria and not our own cells. When a virus infects one of our own cells, it doesn't provide it's own ribosomes – it high jacks the cell by taking over it's ribosomes.

However, at a more complex genetic level, any microorganism which divides rapidly, is subject to more frequent mutations than slower dividing cells. If you grow these infectious organisms in the presence of a drug designed to specifically inhibit a process essential for growth and replication, you are essentially daring it to develop resistance to that drug. Viruses can do this as well as bacteria. Viruses have fewer genes than bacteria do that can develop resistance, but they share the abilities to replicate and mutate rapidly.

 

[herbu]

I mistakenly thought that this virus would bring us all together, like 9/11, and we'd all be pulling the oars in the same direction to minimize and eradicate it.

Hard to do when people laugh and hope Trump and his family get the virus.

 

[Swerd]

Yes, I think that Remidisvir is the most promising drug to try. It was developed to fight Ebola, also a corona virus. It failed. However it has shown activity against MERS and SARS, also Corona viruses.

Minor quibble: Ebola is not a corona virus. It's a filamentous virus from the family of viruses called Filoviridae.

However, both Ebola and corona viruses share the feature of having an RNA-based genome instead of DNA. Because of that RNA genome, they both also share the need to have a viral protease (protein cleaving) enzyme that has an essential role early in their life cycles. Does a drug that inhibits the Ebola protease also work on the Covid-19 protease?

The Italians seem to think it is helpful is Covid 19. I do think this drug is the first one to look at rather then the toxic Plaquenil/Azithromycin combo.

The problem is that the drug is in short supply. It is a drug produced by Gilead Sciences. They are trying to increase production.

Because of short drug supplies, and the emergency need for short term treatments, it's worth investigating all possible drugs.

 

[herbu]

For those who think it's not too bad and the media is blowing it all out of proprtion letme tell you what I am hearing from colleagues in university Medical centers in hard hit New England.

I have a question. We have the most advanced medical capability in the world. We're taking extraordinary measures to contain the virus spread. Yet our medical facilities are overwhelmed and poorly equipped to handle the outbreak.

If you look, you can find that South and Central America, and Mexico, are doing virtually nothing to prepare for or contain the virus. So why aren't we seeing decimation there? Why isn't Mexico City littered with bodies in the street?

Yes, I see Italy and have read the reasons for their impact. But why aren't we seeing that, and more, in other population centers around the world?

 

[Swerd]

Korean researchers looking into different direction: https://www.ncbi.nlm.nih.gov/pubmed/31724441

They are looking into inhibiting the Covid-19 protease enzyme, essential in the virus's life cycle, by a class of chemicals called flavinoids. This is the same enzyme target as Remidisvir. IMO, this is probably worth looking at, but not such a different direction.

 

[KEW]

Hard to do when people laugh and hope Trump and his family get the virus.

Who is laughing?
Where do you see this?
Because I don't!

 

[KEW]

If you look, you can find that South and Central America, and Mexico, are doing virtually nothing to prepare for or contain the virus. So why aren't we seeing decimation there? Why isn't Mexico City littered with bodies in the street?

We do not yet see that type of decimation here!
I suspect the answer to your question is simply that Mexico and Central America do not have as much physical communication with Europe and China as the US does. Travel takes money and these are poor countries.
Unfortunately, I suspect their day is coming. If they are fortunate, perhaps the delayed spread to their country will allow for some improved remedies or at least, improved protocols for preventing spread!

 

[Danzilla31]

Who is laughing?
Where do you see this?
Because I don't!

I can relate I've seen comments and articles and some of the ways people are talking to each other man there is some divisiveness and animosity in this country honestly it's why I got on here and vented the other day was sick of all the bickering especially when your just wanting to get some answers to help you deal with all your worries and concerns about a rapidly changing situations

but America has always been at her best at times in crises it sometimes brings out our best

I really liked that article by that scientist who helped deal with smallpox his message at the end really helped me feel a whole lot better

This situation yeah it can bring out our worst I've felt some off that with my anger and fear in myself as things just changed so fast and were just getting bombarded with all this news and tough news off people dieing of the costs this will have

But what I couldn't see until I read that article is it can also bring out our best too. It's up to me which side of the fence I want to be on

So yeah I've seen some of what he posted my advice to him is rise above it don't let it start to get you down like I was think of what you can do right now for others around u in spite of what some people say or do what can you offer to your community to your family

It snapped me right out of it once my mind got into that mode and I'm doing much better this weekend locking myself down this weekend no longer focusing on the problem I'm trying to think about ways I can be part of the solution. I like that side of myself helluva lot better

 

[TLS Guy]

900 YEAR OLD HOSPITAL PREPARES FOR THE LATEST PANDEMIC

 

[KEW]

I can relate I've seen comments and articles and some of the ways people are talking to each other man there is some divisiveness and animosity in this country honestly it's why I got on here and vented the other day was sick of all the bickering especially when your just wanting to get some answers to help you deal with all your worries and concerns about a rapidly changing situations

but America has always been at her best at times in crises it sometimes brings out our best

I really liked that article by that scientist who helped deal with smallpox his message at the end really helped me feel a whole lot better

This situation yeah it can bring out our worst I've felt some off that with my anger and fear in myself as things just changed so fast and were just getting bombarded with all this news and tough news off people dieing of the costs this will have

But what I couldn't see until I read that article is it can also bring out our best too. It's up to me which side of the fence I want to be on

So yeah I've seen some of what he posted my advice to him is rise above it don't let it start to get you down like I was think of what you can do right now for others around u in spite of what some people say or do what can you offer to your community to your family

It snapped me right out of it once my mind got into that mode and I'm doing much better this weekend locking myself down this weekend no longer focusing on the problem I'm trying to think about ways I can be part of the solution. I like that side of myself helluva lot better

When the news gets too negative for me, I just reduce my input to this ~12 minute clip (Google Shields and Brooks) once a week:
It may have a bit of liberal slant, but they do not take cheap shots or belabor the point. They just make the point. I find getting perspective from a couple of old farts who have been following news and politic for most of my life is reassuring!

 

[Danzilla31]

When the news gets too negative for me, I just reduce my input to this ~12 minute clip (Google Shields and Brooks) once a week:
It may have a bit of liberal slant, but they do not take cheap shots or belabor the point. They just make the point. I find getting perspective from a couple of old farts who have been following news and politic for most of my life is reassuring!

That's cool I'm going to check them out

 

[mtrycrafts]

As with any antibiotic, the more you use it, the more bacteria get exposed to it. And with more exposure, the more likely bacteria will develop resistance to it. That's how multi-drug resistant microrganisms developed – over use.

I understand but pneumonia is already treated with anti bacterial meds and it seems that covid19 brings on pneumonia that causes sepsis to set in an organ failures so why not treat the pneumonia?

 

[Verdinut]

I understand but pneumonia is already treated with anti bacterial meds and it seems that covid19 brings on pneumonia that causes sepsis to set in an organ failures so why not treat the pneumonia?

Some of the pneumonias are viral and cannot be treated with antibiotics. This Covid-19 is a virus as you know.

 

[mtrycrafts]

Yes, there are severe side effects especially from a hydrochloraquine/Azithromycin combination.

...

Yes, but I was specifically asking about the pneumonia brought on by covid19 that seems to be causing sepsis and organ failures to death. Why not treat that pneumonia?

 

[mtrycrafts]

Hard to do when people laugh and hope Trump and his family get the virus.

Maybe that will end his hoax paranoia, or not.

 

[mtrycrafts]

Some of the pneumonias are viral and cannot be treated with antibiotics. This Covid-19 is a virus as you know.

So, pneumonia comes in different uniforms then? Can it be identified quickly in this case to treat them in these patients? Can viral pneumonia be treated?

 

[Trell]

Some of the pneumonias are viral and cannot be treated with antibiotics. This Covid-19 is a virus as you know.

I thought perhaps the antibiotics was helping against secondary infections by bacteria.

 

[Mr._Clark]

Has anyone heard anything about results of the NIH clinical trial of remdesivir to treat COVID-19? So far, I cannot find anything online. The trial started back on February 25 and I find myself wondering if we would have heard something by now if the early signs are good? Perhaps it takes time to get enough patients that meet the criteria?

This is pure speculation on my part, but I find myself thinking that Anthony Fauci must have some access to the early results, and he probably wouldn't be quite so quick to rein in Trump if the early results had been exceptionally positive.

However, I have no personal experience with any of this so I don't know if it anything can be read into the lack of public results and Fauci's statements.

NIH clinical trial of remdesivir to treat COVID-19 begins

Study enrolling hospitalized adults with COVID-19 in Nebraska.

www.nih.gov

 

[ryanosaur]

I had a bout with pneumonia a couple summers ago. Not fun. The specialist I was referred to didn't perform any testing to identify what type I had but treated the resulting infection with antibiotics.
(All this was done while I was not insured, so everything from chest x-rays to the office visits and the pharmacy was OOP. For about a week I was fighting 103ºF fevers with Tylenol and cold showers: the fever would seemingly "break" and come back the next day... wash, rinse, repeat. Took about a full month before I was mostly right, and another 2 weeks before I tried swimming again, so profound was the effect on my respiratory system.)