If music is important to you, I would strongly recommend Salk Sound for your mains and center... they can do double duty for HT, as well, but they very well might be some of the nicest speakers out there for really good accurate music reproduction. Not to take anything away from anybody else, mind.
My experience with Monitor Audio Silver 500 was excellent. I liked them the best of everything I listened too. (They were beat out by a different ID company that is now no longer producing speakers, but Dennis was one of the principle designers with Jim Salk... so his work is still available there.)
My KEF experience left me a little jaded, as I found myself sensitive to their midrange with a little fatigue. Great sound, though, especially the old R900. Martin Logan Motion 60XT was nice, but for the cost didn't outperform the Monitor Audio Silver 500.
If you don't mind horns, I've heard a lot of nice things said about the Klipsch RPs... especially after they tweeked their design some.
Another outlier who had a great review from AVS is the new KLH line with the Kendall towers.
Happy hunting!