The Revel F206/208 didn't sound as transparent as the LS50. I don't nothing about the Ascend but based on available info I assume they would sound a little brighter than the LS50 and therefore more so than the Revel. I liked the Revel in the beginning because they sounded smooth and easy to listen to, but got bored by the end of the audition session, very strong bass though so you won't need a subwoofer. I think they would be excellent for certain kind of music but unexciting in general. If you put them side by side in a crowded amusement park with some Bestbuy Klipsch, you should be able to tell them apart from a mile away.
As expected, you are going to get a lot of opinions, there will be no end to this approach, as we all have our own preferences/tastes. I have 5 pairs of towers and 2 pairs of bookshelves, but if you keep going like this I am sure you will end up having more, if not already.