Ok, small room so tough to get a good picture, but this is the basic room. I'd be putting the speakers on the bookshelf to the right, or possible on top of the desk, but aesthetically the bookshelf makes more sense.
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eeek! Honestly, with that desk and where it is, you are better with a 2.1 desk system like the ones that are setup for work stations. I would instead direct my resources into another space in the house, or rearrange/refurnish that one. If could at least move that desk centered in the space somewhere would alleviate some of the challenges.
Something like the Harman Soundsticks with the small sub that could probably put away in that cabinet when not in use, and then set on the floor perhaps firing half under that desktop when you want to jam. I know you said no sub and that you already have an amp but there are other ways to use them without them being in the way.
ETA: I would likely use stand mounts elsewhere in the room and aim my chair towards wherever that would be when it mattered. Either way, it seems there is going to have to be more than a convenient set and forget setup. Only reason I mention it is because I have lived in places where I had to treat my system like a semi-portable setup, with moving speakers in and out and rearranging a chair or too. Since I tend to listen for 4 hrs or more, it wasn't a big deal. I could also leave them in play when I had the house to myself on weekends and such.