I would like to share my experience with the perceivable effects of Audyssey untweaked, tweaked, and disabled:
Here are the measurements, front left, right, subwoofer left and subwoofer right:
Audyssey tweaked with the Editor app, vs untweaked:
My old ears in my room, and setup could not tell a difference let alone which one sounded better to me.
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With Audyssey disabled:
I would say it sounded not as good to me, so I almost never watched movies without Audyssey enabled.
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Anthem ARC Genesis is not very effective in terms of measured performance, but to my ears, it sounded good enough for me to also almost never watch movies without ARC G enabled.
Above are all from watching movies, I rarely listen to music on that system.