This has been discussed to some extent here already. Logitech leaving the universal remote game is a huge hit to the industry IMO. They had several very strong factors going for them, mostly their very deep library of product that they could control and a actual user interface which allowed end-users to setup and change things. You only needed that ONE person in the home who knew how to set them up, then everyone could benefit from the remote.
I think the second biggest strength of their remotes was Logitech the company. Logitech was able to keep costs in line which really did make the remotes quite affordable. Plus, their build quality was respectable enough and coming from a company that does a ton of human interface devices, so they know their stuff.
A durable, well priced, well supported product that works well? How often does that actually exist in this world? Now they aren't making them anymore, and hearing that customer service is falling off doesn't shock me in the least. The real wish would be that someone would take over for them, or that they would spin it off so it could be just Harmony again, as it started out as.
I am sure there will be more universal remotes that come out which work just fine. But, the history and stability of Harmony is pretty tough to beat.