If it’s 75% music and the room will always be changing, why not go for a Klipsch RP-160m? Even without a sub they’re more than adequate for music, since you can typically get a 30-35hz response in room. They are small enough that transporting them won’t be a pain in the ass, but have enough muscle to fill a large room with high volumes.
I have run them full range on movies and music just to gauge their performance without a sub and in a 2000 cu ft room with reference level playback they handle the low end just fine by themselves without severe distortion or complaints.
Directivity control will reduce the rooms effect on response across the mids and highs as well.