As you already know, I oppose this idea. My reason, however, is not because of any personal adherence to medical ethics – I'm not a physician – and I never took the Hippocratic Oath.\n\nIt would be wrong to abandon the high standards of clinical trial-based evidence that the US FDA requires. If we do it now because of the SARS-CoV-2 pandemic emergency, we will regret it in the future. These high standards have been the result of hard lessons learned in the past when those standards were lower, or did not yet exist. I can think of two examples: Thalidomide and the Polio Vaccine.\n\nThalidomide led to a major change in law in both the USA and the UK.\nhttps:\/\/en.wikipedia.org\/wiki\/Thalidomide_scandal#Change_in_drug_regulations\n\nFortunately, the Polio Vaccine story seems to have ended well. Although the SV40 tumor virus contamination created a real scare, enough time has passed to realize it was probably harmless. In fact, few people outside of biomedical science even know about it.\n\nBoth episodes resulted in a genuine tightening of laws and regulations for testing drugs. They led to a carefully worked out and more rigorous system of testing for safety and efficacy for new drugs that remain as the gold standard.\n\nIn more recent times, I can remember when Interferon was said to be a magic bullet against cancer. It was the first gene product to be manufactured by recombinant DNA methods and was revolutionary for the drug industry in the 1990s. It was widely tested against a number of cancer types, and was reported to have significant positive effects against colon cancer. I recall at least six clinical trials reporting that. Unfortunately, these trials were the small Phase 2 trials. There were not enough patients to allow genuinely significant results, and many of them did not include a control arm where similar colon cancer patients were tested with standard therapy only.\n\nYears later, three very large Phase 3 trials were completed, in North America (USA plus Canada), Asia, and Europe (all the EU plus the UK). All of them produced negative results – Interferon was not effective against colon cancer, and it was significantly toxic when given at the high doses used in the trials. Before those results were available, many oncologist were clamoring for early approval of Interferon. After it was found to be ineffective, the overwhelming opinion among oncologists was that they were glad Interferon was not given an early approval. In fact, the whole Interferon episode was said to be a good example why we must do those large and time consuming Phase 3 clinical trials.\nhttps:\/\/en.wikipedia.org\/wiki\/Interferon#Interferon_therapy\n\nThe bottom line – wait for the results of properly designed large Phase 3 clinical trials. Don't allow panic to bust the drug testing & approval system. We worked very hard in the past to get it as good as it is now.\n\n\nI'm sorry, but we have to think out of the box on this one. Populations are just not going to put up with these onerous containment measures much longer. You can see them breaking apart quite rapidly. Frankly, the world's economy can not take this much longer, certainly not until 2022. Academics can rave all they want, but I'm telling you that is not going to stop a different approach here. I know most practicing, and retired physicians view this way the same way I do. The ICU staff can not keep up this pace any longer world wide. They are seriously run down and will start quitting in increasing numbers.\n\nThat is why I strongly favor going to viral challenge studies. That will tell us above all effectiveness and a lot about safety. We are just not going to be able to go for the level of safety we normally do here. There are just too many deaths, permanent injury and economic disruption. We really do need to approach this with a war mentality.\n\nSo, if Trump and Boris Johnson and others force the issue on this one, they will have my support. I can tell you right now, dragging this out until 2022 by slavishly adhering to usual protocol is not going to happen, and nor should it, otherwise needless lives will be lost.