Can we come away from this thread with any useful information or guidelines?
I'll see if I can provide a few useful thoughts.
First, one should keep in mind that bookshelf vs tower is a bit of a misnomer, as some larger bookshelf speakers can really blur the lines, while some towers aren't much more capable than a small two-way bookshelf speaker. Ultimately, the question is this: how much extension and output should one purchase?
Extension is the simpler part of that equation, and obviously the key point is whether or not your crossing over to a subwoofer.
The question of output is a bit more complicated, and obviously depends on your listening habits. If you're looking to turn things up to 11, power handling, sensitivity, and volume displacement all matter. Even with the benefit of an 80Hz XO, reference levels are extremely demanding, and realistically beyond what you can expect a run of the mill 2-way 5" speaker to deliver cleanly. To put some numbers to it, consider the throw required to deliver 100dB at 80Hz at 1m for a 5.25" driver vs 2x6.5" drivers. The single 5.25" would need to be quite stout indeed, as it would have to move a little over 6mm one way. The pair of 6.5" woofers would be loafing along by comparison at 2mm one way. You'd also have a power handling advantage given that the power would be split between a pair of voice coils.