See, now this I just disagree with. We are talking about a quality amplifier designed to deliver a true 35-60 watts to each speaker as an 8ohm load. The wiring will be typically adequate to get that amplified audio to the speakers, and we are talking about a quality pre-amp not a volume control in the rooms or a lousy 70 volt system like in business applications.
The only real limiting factor of the setup is the speakers and acoustics of the room.
But, I promise you, it's going to sound a lot better listening to that audio in your study than cranking up the music room audio just so you might hear it, barely, in the study, while anyone near the music room is getting blasted.
For music, I think there is nothing better than good distributed audio with one touch access and availability. It adds music to your home in a way that a single listening environment simply can't touch.
It doesn't replace the nice home theater setup, it just enhances the entire living experience, and when dropping $300,000+ on a home (which is low in my area), spending $10,000 on the audio to enhance it really isn't a ton of money. Another $10,000 for a home theater setup is appropriate as well.