That may not be practical. In most cases we're talking about levels of distortion that are below the perception level that makes things obvious. Even with tube amps we're usually talking about frequency response aberrations more than we are distortion.
The challenge is that humans often respond to influences that aren't obvious. Background conditions that you learn to ignore can still fatigue you.
This test was run at a level of 40db, which is very quiet. I wonder how seriously listening to music compares to mental arithmetic?