When you have 2.5k budget for the whole thing including TV ....
Not impossible, but a bit harder to work with....
Ascend Speakers , mentioned above, are a great choice, but might be a bit over your budget.
I highly recommend to check out Pioneer Speakers - 2011 models are frequently on sale at newegg, but 2012 models still very affordable and offer performance improvement over older models. Andrew Jones - Chief Speaker Designer for Pioneer and TAD Lab (which sell 100k speakers) went to great lengths to insure best possible quality at their price point.
Subwoofers - HSU (and Outlaw) , Rythmic and SVS are the brands I'd be looking
for example great deal on this sub:
STF-2 Subwoofer
Final decision will have to be based on a) (most important) Size of room (total open volume) and b) Your budget
Receiver - many people praise refub models from AC4L. Including Denon 1912 and Onkyo 709 are ones I recommend most often
TV choice will be yours, but I could not recommend enough a Plasma TV from Panasonic - ST30 are last year models - If you can find one - they usually sold at large discounts
I bought my TC-P55ST30 earlier this year for $980+$140 shipping (which I was able to refund due to several shipping issues)
I used decide.com alerts to get best price - Highly recommend to check them out.