The old "my wife can even hear the difference (tho usually it's 'night and day')" isn't new but the "from 3 rooms away" part is. From 3 rooms away is even more problematic than sighted comparisons.
The fooling comes when you're influenced by expectation bias and placebo. You brought up wine tasting... actually you brought up like 4 of the top 5 arguments most subjectivists use, lol. Here's an interesting article for you.
Noses have been put out of joint in the wine industry, with experiments showing that even experts can't always tell cheap plonk from grand cru. David Derbyshire reports on the chemistry behind the taste
www.theguardian.com
I believe you when you say you can hear a difference. The placebo effect is very real, testable and everyone is susceptible to it. I try to do my best to minimize my biases when offering advice, doing comparisons or making expensive decisions tho... I really believe you might be surprised if you participated in a DBT and did a proper comparison.
More often than not when folks come here seeking improvements they end up finding it with better speakers or subwoofage. If you have sufficient power more or different amplification is a lateral move of very little (if any) significance.