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My biggest question is say I want to use the Blu-ray unit. Can this be programmed to use it, move around in it and say go to Netflix and at the same time control the audio on the AVR and Netflix functions? That is what I am after.
Thanks again for all the input.
Yes, that's the whole point of the remote. Certain buttons, like Volume, are "punch-through." They are active in all modes.
So if you setup a macro on the 650/665 (sounds complicated but the software takes you step by step and is super easy) to watch Blu-Ray. When you push the button it turns the TV on, the blu ray, the AVR on and selects all the correct inputs and modes. Everything is on and ready for you to put in the blu ray or use the smart functions.
Except for punch-through buttons the remote itself will be setup to use the blu ray player with all the features AND the important buttons from other device (the punch-throughs). Therefore, if you want to watch Netflix you use the button next to the LCD display where it say Netflix.
Not having everything is great for general watching and keeping other people from accidentally making changes.
Indeed, if you really want to fiddle with the AVR, you'll need select the AVR specifically on the remote. However, you can very simply, in the software, program more punch-through buttons. And you can add/remove/move around item's in the LCD display.
For instance, I used the colored buttons (red, green, blue, and yellow) on the 665 to punch-through AVR sound modes. If I'm watching Roku and decide listen to music through Plex, I can select yellow to put the AVR in multi-channel stereo mode (as opposed to 2x stereo). Similar for going back. This doesn't interfere with using the Roku.
BTW, with the OEM remote I can't go directly to multi-channel mode. I have to pull up a menu and scroll to it. I also put Netflix and Hulu on the top LCD screen in Roku mode for easy access. In some cases you will get added functionality.