Hey Tim, the short answer is: No. As long as your receiver is setup correctly.
Here's the long answer: I'm not familiar with the Denon receivers, but I imagine it's got something similar to Yamahas YPAO for auto setting the distance, levels, etc? If not you could use an SPL meter to set your levels.
Here's how I set up my old system. The centre was being powered by a denon amp (POA-5200), the mains were being powered by a Behringer A500, the subs were being powered by an A500, and the rears were being powered by the receiver (Yamaha RX-V1500).
The denon amp has no gain control, it's a simple on off, so it was simple, just plug into the receivers RCA out and go. The behringers have gains, similar to the Yamaha power amps, and I set them at roughly 45% of max. Why? Because with the speakers hooked up to the amps, and nothing being input to the amps, the noise level from the amps started to get noticable at around 50% gain. You may get a mild hum or pink noise from a power amp if you turn the gain up too high. I used to have a ground loop fault in the wiring in my house, so it was very noticable through the power amps...
Anyway, once everything was hooked up, and the gains all set at roughly 45%, I simply powered up the receiver and used the YPAO mic to auto tune itself. Again: you can use an SPL meter and a measuring tape from the main listening position to do a similar job.
When watching movies, ie. the chopper scene from Apocalypse Now, all speakers would play at the same level, making the sound very transparent. Of course I programmed the Dolby PLII Music listening mode to shift about 80% of the sound to come from the front mains, utilizing the higher headroom of the behringers and giving the rears a break from the workout.
I imagine the Denon would allow you to customize it's PLII decoders to send more to your mains while listening to music...
Good luck!