Sorry about that.
The interfaces are Universal Audio Volt 4 and PreSonus ioStation 24C. (These are not connected at the same time.) They receive input via USB-C from the PC. (Pan and volume controls have been checked.)
The interface's TRS 1/4" outs feed TRS 1/4" ins on one of the three tested amps (Crown XLS1002, Behringer A800, Hafler TA1600). Speakers are all connected to the amps via banana plugs. Speakers if it matters are JBL 4206s, KRK Rokit 8s, and Event 20/20s.
Why and how would panning hard left or hard right play perfectly as if panned to the center position (stereo separation, clarity, depth)? When set to the center position, sound on one of the speakers becomes significantly degraded as if out of phase - the same speakers that just played perfectly 30 seconds prior on the panning test.
On the second series of tests, I used an acoustic/ vocal track. This time I only connected a single speaker at a time switching between left and right outputs. Regardless of side, the lead vocal in the track disappeared with backgrounds and guitar remaining (as if someone connected a vocal eliminator to make an instrumental). How can a single speaker be out of phase? There's nothing to be out of phase with!!
My brain is tired. I haven't been this befuddled dealing with audio in 30 years. I feel like I'm doing something stupid, but I can't figure out what.