I think both distance from the speaker and the overall room makes a difference in terms of the choice of speakers. Like having ginormous towers in a small room where you're sitting fairly close wouldn't be something I'd do....or the opposite like in Pogre's thread, the Take 5 system get somewhat lost in a large room. As to any specific predictions as to the dimensions/drivers/design of the speaker to the room and listening distance, don't know of any particular guidelines to point you at on the other hand.