The most important thing is the volume/gain level.
For example, when I watched "Black Hawk Down" on blu-ray, I remember the difference in sound level was tremendous between the PCM and the DD tracks when switching back and forth. I would say the PCM was probably 4 or 5 dB LOUDER.
It could also be the other way around. One reviewer (DVDTown) noticed that the "Iron Man" blu-ray's DD track was 4 dB LOUDER than the TrueHD track.
My thinking is that the difference in volume levels are not just limited to the Center or Front Left or Front Right. The difference could also be significant in the Surround channels.
The problem with receivers and pre-pros is that once you do the initial setup (level matching), you think you are all set for every movie.
But the fact is, some movies will have the center channel too high or too low, or the front left & right too high or too low, or the surrounds too high or too low.
I usually have all three volume knobs set at the 9 o'clock position. This gives me a 65dB on the SPL meter for all channels.
But if I feel that the movie is just too loud, I turn down the front left and right volume just a hair.
If I feel that the center channel(dialogue) is too low, I turn the center volume up just a hair.
If I feel that the surround channels is too low, I turn the surround left and right up just a hair.
And, of course, if I feel that the BASS is not enough, I crank up that volume knob on the subwoofer itself.
Now it sounds just perfect to me.