Running wire really depends on your confidence. No A/V skill at all is required to run wire... What you need are some good mechanical skills. Find out which way joists run, figure out what the path to the speaker locations would need to be.
It may not be feasible to get the speakers where you want them without cutting quite a few holes into the drywall. This is something that 'pros' will do as well if there isn't good enough access, but then they have flexible and long drill bits to make the job easier and it may be better to call someone in. But, it really depends on your confidence level, your skill with spackle and a paintbrush comes into play as well.