Well...
There are a few ways to make this work.
1) Use flat speaker wire that can be painted over and you will never know it is there.
2) Pull off the baseboard, slot the drywall, run the wire to where the speakers will be, cut a small hole (behind where the baseboard covers), cut a hole where the speaker will be located, and then fish your wire up the wall. Shouldn't be too hard, unless you have fire blocking in the walls.
3) Get a friend who knows what he is doing
Hope that helps
Also if you never do it, you will never know if you can. Mistakes can be covered up by drywall patches and paint.