It depends, there is wiggle room with possible settings, and speaking of room, the room itself is inflicting it's own acoustic molestation on those low frequencies.
For reflex loaded mains the general rule of thumb is to high pass an octave above the speakers acoustic roll-off, so for your example and assuming a reflex alignment, the hpf should be 60hz as a starting point. (The rationale is to sidestep the phase shift inherent to reflex loading, making the crossover to subs easier to accomplish, whether that's you calibrating manually or relying on automagic room correction/sub calibration.)
Higher hpf settings can be used to address the idiosyncrasies of particular setups, e.g. TLS' in-wall family room system. You do it too in at least one of your rigs, don't you? As long as the sub has extended enough high end response to do it and are somewhat co-located with the mains to avoid localization issues, no problem with a higher hpf setting.
Sealed mains are a slightly different beast. I have a rig with sealed mains that somewhat adhere to the old THX standards, rolling off at the expected 12db/oct, and the hpf ended up directly coinciding with the speaker's roll off. Based on the ol' polarity reversal test, it results in an almost ideal LR4 alignment and works very very well.
So, yeah, some wiggle room exists, and each room demands empirical evaluation and adjustment to arrive at what works best.