If anyone likes you enough to watch a movie with you, the center channel must reproduce all that content smoothly and predictably across all your seats. If you’re sitting perfectly in front of the center channel, having multiple drivers of the same type in a horizontal configuration can do the job just fine. But if you move slightly off-axis, or as any of the other seats will realize, having horizontally-aligned redundant drivers will cause some frequencies to be canceled and some to be reinforced. This phenomenon is called wave interference and you can read more about a double-slit experiment with light (or any other physical media that behaves in waves) here. The subtracting and adding of various frequencies at various angles can result in audible shifting in the speaker’s sound across the room. Not only does the off-axis frequency response suffer, but timing and phase response follow. Off-axis, MTM speakers can often sound hollow but the comb filtering, or lobing effect, can also shift the imaging away from the middle as a “phasy” sound. There’s a good reason why one-piece surround speakers use a lot of identical drivers (up to 40 - wow). The wave interference in those cases is used as a tool of good, not evil. To compensate for the lack of intelligibility (of the audio, not the script), people typically turn their volumes up which then can then result in some domestic tension among spouses, children and neighbors.
Floor speakers with multiple vertical redundant drivers will also have wave interference, but vertical variation in frequency response is much less of a problem than horizontal variation. In fact, the more identical drivers a loudspeaker has, the more it behaves like a line source instead of a point source. Line sources radiate in a more cylindrical pattern, which is advantageous if it is vertically oriented, as line sources interact less with the floor and ceiling. But a cylindrical radiation pattern is a disadvantage if you arrange the redundant drivers horizontally. The speaker will then interact more with the floor and ceiling, and suffer poorer response horizontally across the room.