If you set the L/R/C to large, then the bass will not be redirected to the sub - they get a full range signal. Only the LFE will be sent to the sub.
If the Denon has a setting like LFE+MAIN, Both, or Plus (varies from receiver to receiver - my Onkyo calls it 'Double Bass') then bass will be redirected to the sub in addition to the large speakers.
Generally, its better to set all speakers to small, sub=yes, with an appropriate crossover frequency. Then all bass below the crossover will be sent to the sub, in addition to LFE in DD tracks.