Any consideration to using plywood over MDF to help keep the weight down? You're going to have ~170 lbs in drivers alone in the box. I think if I was going the fewer/high quality driver route (in this case with 2 drivers), I'd go with single drivers and make two boxes. With the current plan of action, you'd still have the same room mode issues as you would any single sub, but you have the additional problem of having an extremely high bar to clear with the performance requirements for a second sub so you aren't holding back the DuOp Ultras. Of course, if you match it with an identical sub, that's not an issue...
What are you looking to power those with? One of those LG clone amps perhaps?
At any rate, good luck w/your project.