I find ECO mode reduces the temp by around 10 degrees F!
As Verdinut implied, it only effects the amplification section, downstream of the pre-outs, so if you run all external amps, it is a no-brainer. Personally, I would not hesitate to use ECO mode with the internal amps (aside from the front three channel).
I did not notice an audible difference between with and without ECO, but figure I won't take the chance on the front 3 since I have external amps available.