M
Mr._Clark
Audioholic Samurai
Unfortunately, it seems as if almost everyone will probably get it sooner or later.
This SNL "Ad" is in poor taste, but it is somewhat humorous:
"Let our rigorous testing and reviews be your guidelines to A/V equipment – not marketing slogans"
This SNL "Ad" is in poor taste, but it is somewhat humorous:
Teetertotter?
Audioholic Chief
We celebrated our family Christmas on December 10, with some nieces and nephews, grandkids and families and 2 GG kids, plus daughter and son, etc. We celebrate early as leaves them for other immediate family on Christmas. No one with COVID, flu, and other stuff. Wife and I live in Wisconsin and others are within 1-1/2 hours driving and daughter up from FL. Daughter is not vaccinated, but takes a couple COVID tests before she visits.
All others had their shots, including some boosters. Wife and I are 80 and have not traveled in 3 years with no future plans. We do have some close church friends and go out for dinner as a group every so often and after church, go have breakfast at a local establishment. It is hit and miss with who goes for breakfast.
COVID and other diseases have been nonexistent with our families. Everyone seems to be cautious in their own way and my wife is in contact weekly, with family.
I have Kiwanis once a week and with WI., winter, son and I play indoor simulated 2 man golf league, one evening a week. Wife does activities with 2 of her friends or talk a lot..........Seems like we are grocery shopping or finding things we need 4 times a week....lol. His and hers cars are in good shape with LIFE being GREAT!
All others had their shots, including some boosters. Wife and I are 80 and have not traveled in 3 years with no future plans. We do have some close church friends and go out for dinner as a group every so often and after church, go have breakfast at a local establishment. It is hit and miss with who goes for breakfast.
COVID and other diseases have been nonexistent with our families. Everyone seems to be cautious in their own way and my wife is in contact weekly, with family.
I have Kiwanis once a week and with WI., winter, son and I play indoor simulated 2 man golf league, one evening a week. Wife does activities with 2 of her friends or talk a lot..........Seems like we are grocery shopping or finding things we need 4 times a week....lol. His and hers cars are in good shape with LIFE being GREAT!
Eppie
Audioholic Ninja
Blocked in Canada
but I managed to find it. Seems only material that is over 1 year old is freely available on their Youtube page. Yeah, SNL has a funny twist on these things. 
cpp
Audioholic Ninja
The news in our paper this morning " Could the COVID-19 surge in China unleash a new coronavirus mutant on the world? "
I guess they will just keep on making new variants until their whole country is protected as they unleash these new variants on the world population. Just my odd weird opinion.
I guess they will just keep on making new variants until their whole country is protected as they unleash these new variants on the world population. Just my odd weird opinion.
Teetertotter?
Audioholic Chief
They have yet to come out with long term effects on your health and advertise with vengeance.....if the case.
We have our shots and still more cautious what and where we go or do.
We have our shots and still more cautious what and where we go or do.
mtrycrafts
Seriously, I have no life.
Hard to know what the long-term effects are after only about 2 years out there. Takes time. I would think the experts can make an educated prediction but not from
actual effects.
M
Mr._Clark
Audioholic Samurai
Eric Topol posted on his blog about yet another new variant, XBB.1.5 that is apparently becoming more prevalent in some geographic areas. It appears to me that there is not enough sequencing data right now to know for sure exactly what it is happening with this variant.
>>>New York is the bellwether for what is happening with XBB.1.5 and it doesn’t look good with a marked rise in hospitalizations, especially among seniors, in recent weeks as this variant has been taking hold. Of course, other factors are likely contributing such as waning of immunity, indoor/holiday gatherings, cold weather, lack of mitigation. But it is noteworthy that New York’s Covid hospital admission rate is the highest since late January (and also exceeds the summer 2021 Delta wave, but with some ambiguity as to how hospitalization were categorized then and now). . . . So we don’t know for sure how much of this is being driven by XBB.1.5, but it doesn’t look favorable. <<<
https://substackcdn.com/image/fetch/f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5a581203-c374-42f5-9699-36c3ccf52560_5988x1982.png
On the other hand, he suggest that the bivalent booster is likely to be effective:
>>>Although we don’t know how well the bivalent booster does against XBB.1.5 yet, there’s no reason to think it would not be helpful added antibody protection compared with not getting the booster. So if you haven’t had a booster in the past 4+ months, this would be well advised.<<<
As the Sergeant on Hill Street Blues said "Let's be careful out there"
>>>New York is the bellwether for what is happening with XBB.1.5 and it doesn’t look good with a marked rise in hospitalizations, especially among seniors, in recent weeks as this variant has been taking hold. Of course, other factors are likely contributing such as waning of immunity, indoor/holiday gatherings, cold weather, lack of mitigation. But it is noteworthy that New York’s Covid hospital admission rate is the highest since late January (and also exceeds the summer 2021 Delta wave, but with some ambiguity as to how hospitalization were categorized then and now). . . . So we don’t know for sure how much of this is being driven by XBB.1.5, but it doesn’t look favorable. <<<
https://substackcdn.com/image/fetch/f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5a581203-c374-42f5-9699-36c3ccf52560_5988x1982.png
A new variant alert
The XBB.1.5 variant is on a growth spurt in the United States
erictopol.substack.com
On the other hand, he suggest that the bivalent booster is likely to be effective:
>>>Although we don’t know how well the bivalent booster does against XBB.1.5 yet, there’s no reason to think it would not be helpful added antibody protection compared with not getting the booster. So if you haven’t had a booster in the past 4+ months, this would be well advised.<<<
As the Sergeant on Hill Street Blues said "Let's be careful out there"
cpp
Audioholic Ninja
And they have an abundance of "numerous people "
Mikado463
Audioholic Spartan
the Chinese call that 'thinning the herd' .......
mtrycrafts
Seriously, I have no life.
And the herd is very large.the Chinese call that 'thinning the herd' .......
GO-NAD!
Audioholic Warlord
I think we have similar patterns amongst Conservative party supporters in Canada, as well.
How Many Republicans Died Because the GOP Turned Against Vaccines?
Party leaders are unquestionably complicit in the premature deaths of their own supporters.
www.theatlantic.com
M
Mr._Clark
Audioholic Samurai
It looks like XBB.1.5 is rapidly becoming more prevalent (I believe the CDC numbers are estimates, so it's not clear exactly how many cases are caused by XBB.1.5).
>>>Dec 30 (Reuters) - Over 40% of COVID-19 cases in the United States are now caused by the highly contagious Omicron XBB.1.5, data from the U.S. Centers for Disease Control and Prevention showed on Friday, with the subvariant doubling from the previous week.<<<
https://www.reuters.com/world/us/omicron-subvariant-xbb15-accounts-405-us-covid-cases-cdc-2022-12-30/
>>>There’s no indication it causes more severe illness than any other omicron virus, Dr. Barbara Mahon, director of CDC’s Coronavirus and Other Respiratory Viruses Division, told NBC News.
While overall Covid hospitalizations are rising around the country, areas such as the Northeast that have seen high levels of the new variant have not experienced a disproportionate increase in hospitalizations, Mahon said.<<<
What is the XBB.1.5 subvariant? CDC reports a new strain of omicron taking over in the U.S.
About 40% of confirmed U.S. Covid cases are caused by the XBB.1.5 strain, up from 20% a week ago.
www.nbcnews.com
The nbcnews.com article has a link to a letter published in the NEJM, which found that the bivalent booster had a better neutralizing antibody response to XBB than the original boosters (XBB.1.5 was not included)(and, of course, it didn't look at T cell response).
>>>Persons who received either one or two monovalent Covid-19 vaccine boosters had much lower neutralization activity against omicron subvariants (especially against BA.2.75.2, BQ.1.1, and XBB, which contain the predicted escape mutation R346T) than that against the WA1/2020 strain. Persons who received the BA.5-containing bivalent booster had better neutralizing activity against all omicron subvariants (especially against BA.2.75.2, BQ.1.1, and XBB) than those who received either one or two monovalent boosters, even though the neutralization GMT against WA1/2020 was similar in the cohort that received the two monovalent boosters and the cohort that received the bivalent booster. These responses are consistent with recent observations in persons with breakthrough omicron infection showing broadened neutralizing activity against omicron subvariants.5 Limitations of this study include the small cohort size, differences in age among the cohorts, the unknown effect of previous exposure to SARS-CoV-2, and comparison of the vaccines at a single time point. These serologic data show an overall neutralization benefit with bivalent booster immunizations.<<<
The NEJM study should probably be taken with a grain of salt because there were only 35 people total (three cohorts of 12, 11, and 12 people).
Swerd
Audioholic Warlord
In addition to the small sized cohorts that you mentioned, the authors mentioned other possible limitations:
- Difference in ages among the cohorts.
- Unknown effect due to previous SARS-CoV-2 infections. (These first 2 are probably the results of a quick study, as opposed to a more carefully selected patient population that I'd expect in a larger clinical trial.)
- And, probably most important, this study tried to compare the antibody based neutralizing effect of different vaccines that were not given at the same time. We already are well aware that the circulating antibody levels raised by these anti-Covid-19 vaccinations drop noticeably some 6-9 months after they've been given. Again, a proper clinical trial would have tested antibody levels in people vaccinated at similar times.
And thanks for mentioning the lack of any T-cell response data. I've trained you well
.
mtrycrafts
Seriously, I have no life.
How did the Q-cells respond though?...
And thanks for mentioning the lack of any T-cell response data. I've trained you well
Swerd
Audioholic Warlord
Q-cells are something that mainstream immunologists don't regularly mention. Even their existence is considered highly controversial. There are more than a few highly influential B- and T-cell immunologists who forbid any discussion of Q-cells in their labs.How did the Q-cells respond though?
It is said that Q-cells were first described growing in cell cultures obtained from a yoga guru who suddenly died from unknown causes. Others claimed that Q-cells could also be obtained from individuals who practiced other forms of 'wellness' or who harbored elaborate and unlikely conspiracy theories. One study demonstrated that the best growth medium for Q-cells contains the blood from juvenile humans who had been kidnapped and subjected to satanic torture. As a result, these were at first called QAnon cells. But later, the more standard term Q-cell was adapted.
Q-cells were shown to be another white blood cell that developed from never previously described bone marrow precursor cells. If these precursor cells were exposed to 5G wireless internet signals while in culture, they produced abundant amounts of infectious virus particles, later identified as SARS-CoV-2. These viruses infected and killed B- and T-cells, but the progeny of these precursor cells, the Q-cells, survived unharmed.
I'd cite references from the scientific literature, but all of these have been deleted from online science libraries. Apparently, all this had been predicted by L. Ron Hubbard in his book "Dianetics".
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cpp
Audioholic Ninja
I like it how now the Online activists are blaming COVID for the on-field collapse of American football star Damar Hamlin. The team and his physicians say the most likely cause is an arrhythmia that occurred as a result of the blow to his chest. But NO its blame the vaccine. Might as well blame the vaccine for everything.
everettT
Audioholic Spartan
Yeah it's been pretty loud and considering that his Doctors don't have a definitive answer, it's not very constructive. It doesn't help that they mRNA vaccine manufacturers weren't forthcoming with their trails and the rate of myocardial issues in people under 30, which fuels speculation. There's a place for discussion but not speculation.
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