M

Mr._Clark

Audioholic Samurai
Ivermectin has been sold for a number of years as a low-cost generic drug. Big Pharma won't touch a product unless its still under patent protection, allowing a high price.
I don't know about Big Pharma, but there are plenty of companies that pursue patents on Method of Treatment patents using repurposed drugs.

>>>[C]ontrary to the conventional wisdom that MOT patents are second-tier to composition patents, companies are repurposing drugs, protecting them with MOT [Method of Treatment] patents, and realizing significant successes for their efforts.

Some of the world’s most successful drugs were actually discovered through repurposing efforts and are or were at least originally protected only by MOT patents. . . .

MOT patents are not necessarily as limited as one might think. Rather, MOT patents also provide their own advantages such as strategically carving out exclusive markets for the repurposed drug, providing tactical leverage in licensing, and potentially extending market exclusivity to keep competitors at bay <<<


In my opinion, the article above is a little over the top in terms of "selling" the benefits of MOT patents, but there is nevertheless a financial incentive to pursue MOT for generic drugs.
 
Swerd

Swerd

Audioholic Warlord
I don't know about Big Pharma, but there are plenty of companies that pursue patents on Method of Treatment patents using repurposed drugs.
That might be of interest, only if ivermectin were actually an effective method of treatment for Covid-19. It ain't.
 
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Swerd

Swerd

Audioholic Warlord
In the earlier article, Mills mentioned that on its own its useless, but as part of a yet undiscovered cocktail of drugs it maybe effective. He points out how they treat HIV as an example. They are continuing to study different combinations of drugs to come up with something.
That's complete and utter nonsense. That implies that ivermectin, combined with the right drug might be effective against a virus infection. That's like saying we might be able to treat cancer if we combined athlete's foot ointment with Preparation H.

All the individual drugs in the HIV cocktail are anti-viral drugs. When given alone, they aren't effective enough, but when combined they are synergistically effective – they are more effective than the added effects of each individual drug.
 
SithZedi

SithZedi

Audioholic General
That's complete and utter nonsense. That implies that ivermectin, combined with the right drug might be effective against a virus infection. That's like saying we might be able to treat cancer if we combined athlete's foot ointment with Preparation H.

All the individual drugs in the HIV cocktail are anti-viral drugs. When given alone, they aren't effective enough, but when combined they are synergistically effective – they are more effective than the added effects of each individual drug.
Maybe you are correct. Then again, here is a cut and paste from the interview from the posted Mills.

EM: I am not advocating the use of ivermectin until we have good, quality evidence from clinical trials that it is effective.

Here’s the thing: The people who wrote that article [in the American Journal of Therapeutics] claimed that this drug [ivermectin] is a miracle drug that has an effect of about 75% of reducing mortality. That is not far off the effect of a parachute when you jump out of a plane. It would not take much of a clinical trial to know whether that was true or not, and almost every physician would be able to spot really quickly whether there was a drug that miraculously was helping people. But we’re not getting that feedback from physicians and every decent clinical trial that is done on it concludes that there might be a treatment benefit, but it’s not obvious. Whether the drug has an important treatment effect or not, it’s just not going to be as large as what they claim.

LP: So you’re saying — looking at it in a positive way — ivermectin could be one of a group of drugs that would be used, for instance, in treating COVID, but not necessarily just on its own?

EM: That’s correct and almost always in infectious diseases, we require a group of drugs. It’s very rare that one drug is the drug that ends a condition. So if you look at HIV, for example, it’s usually a three-drug cocktail that’s required. Individually, those drugs are almost useless. But you put them together, they’re magic. Hepatitis C, it’s a two-drug combination. Individually, it was really painful for people, but you put them together and you get a cure. That typically is the way that it is with infectious diseases. We’re going to be looking at combinations of drugs.
 
M

Mr._Clark

Audioholic Samurai
That might be of interest, only if ivermectin were actually an effective method of treatment for Covid-19. It ain't.
I think we're talking past each other.

I'd agree that there doesn't seem to be much incentive to continue studying ivermectin as a treatment for COVID at this point.

There has been a narrative that the alleged lack of money in ivermectin (or, more money in other drugs) is the reason it was not being used. Here's an example:

>>>For people inclined to be suspicious of government scientists and federal policies on issues such as mask-wearing, ivermectin filled the place of the failed hydroxychloroquine as an alternative to the official federal guidance on how to prevent and treat COVID-19.

"It fits into the bigger narrative about the so-called 'medical deep state' [in which] scientists, pharmaceutical and political elites have an interest in making people use more expensive, experimental drugs" to increase the profits of the pharmaceutical industry, Yang says. "And they have an interest in not showing the public the cheap, widely available drugs that can supposedly cure COVID-19." (Ingraham has labeled Dr. Anthony Fauci as part of the "medical deep state.")<<<


I realize you are not promoting a medical deep state conspiracy theory. Nevertheless, for someone who is inclined to believe such things, I would point out that there are financial incentives to investigate new treatments using old drugs.

In fact, one of the doctors (Thomas Borody) who has been promoting ivermectin filed a patent application for a method of treating COVID:


The notion that those pedaling ivermectin are acting for purely altruistic reasons (in contrast to the greedy/evil drug companies) strikes me as being naive (For clarity, this is just a general comment, I'm not saying you are pushing this narrative).

In the for what it's worth department, I conducted a brief search to see what the status of Borody's patent application is. He may have filed more than one, but the one I located is US Patent Publication No. 20210330663 (if anyone is interested in looking at it, one easy way to get a .pdf copy is to go to www.pat2pdf.org and enter 20210330663).

All documents in pending U.S. applications that have been published can be accessed at: https://portal.uspto.gov/pair/PublicPair

Briefly, his patent application was rejected under 35 U.S.C. 112 1st paragraph in an Office Action dated 12/20/21 for 1) failure to show possession of the invention (i.e. failure to adequately describe the specific combination of elements claimed), and 2) for failure to meet the enablement requirement (i.e. failure to show that the specific features that are claimed actually work). I'm not sure if he will be able to overcome these rejections, but it looks like an uphill battle. Even if these rejections are overcome, the application could still be rejected as unpatentable over the prior art (the first Office Action did not include any prior art rejections).

That got quite far off topic, but I thought people might be interested in seeing what is actually happening in this patent application.
 
GO-NAD!

GO-NAD!

Audioholic Spartan
Ivermectin has been sold for a number of years as a low-cost generic drug. Big Pharma won't touch a product unless its still under patent protection, allowing a high price.
Why is it, that penicillin is so expensive in the US?
 
M

Mr._Clark

Audioholic Samurai
Ivermectin has been sold for a number of years as a low-cost generic drug. Big Pharma won't touch a product unless its still under patent protection, allowing a high price.
No offense, but this post is somewhat puzzling to me.

Merck manufactures ivermectin:

STROMECTOL (ivermectin - tablet;oral)

I realize the 6MG tabs has apparently been discontinued, but the 3MG tabs are apparently still available.

With $48 billion in revenue, Merck was the 4th largest pharmaceutical company on the planet in in 2020:

>>>Here are 10 of the largets pharmaceutical companies, ranked by revenue:

1. Johnson & Johnson:- $82.6 billion

2. Roche: $58.3 billion

3. Novartis: $49.9 billion

4. Merck: $48 billion

5. AbbVie: $45.8 billion

6. Bristol-Myers Squibb: $42.5 billion

7. Sanofi: $42.3 billion

8. Pfizer: $41.9 billion

9. GlaxoSmithKline: $34 billion

10. AstraZeneca: $26.6 billion<<<


I might be crazy, but Merck kinda seems like "Big Pharma" to me, and it kinda seems like Merck is touching ivermectin.
 
M

Mr._Clark

Audioholic Samurai
This is interesting. This guy apparently didn't just have "long COVID," but rather had an active infection for a long period of time and his body couldn't fight it off.

>>>A vaccine has been used to free a man who was trapped at home by a Covid infection that lasted for more than seven months.
It is the first time that a vaccine has been used to "treat" Covid rather than "prevent" it.
Ian Lester, 37, has a weakened immune system that was unable to defeat the virus on its own. . . .

The difference in Ian's body [after getting vaccinated] "was like night and day", says Dr Ponsford. The first dose started to build his immunity, but it took a second dose to reach the point where his body could fight off the virus. By the end of August, Ian was testing negative again.<<<


I do wonder if intentionally giving someone the vaccine right after infection would be effective (and safe). I'm assuming there's a risk that it would cause the immune system to react too strongly. On the other hand, I know a guy who got boosted and was then exposed to the virus a day or two later. He then tested positive, but he had a mild case. I certainly can't prove it, but I'm guessing that the booster might have kick started his immune response somewhat (I realize this is anecdotal, and getting boosted just before exposure is not the same thing as getting vaccinated after getting infected, etc.)
 
highfigh

highfigh

Seriously, I have no life.
No offense, but this post is somewhat puzzling to me.

Merck manufactures ivermectin:

STROMECTOL (ivermectin - tablet;oral)

I realize the 6MG tabs has apparently been discontinued, but the 3MG tabs are apparently still available.

With $48 billion in revenue, Merck was the 4th largest pharmaceutical company on the planet in in 2020:

>>>Here are 10 of the largets pharmaceutical companies, ranked by revenue:

1. Johnson & Johnson:- $82.6 billion

2. Roche: $58.3 billion

3. Novartis: $49.9 billion

4. Merck: $48 billion

5. AbbVie: $45.8 billion

6. Bristol-Myers Squibb: $42.5 billion

7. Sanofi: $42.3 billion

8. Pfizer: $41.9 billion

9. GlaxoSmithKline: $34 billion

10. AstraZeneca: $26.6 billion<<<


I might be crazy, but Merck kinda seems like "Big Pharma" to me, and it kinda seems like Merck is touching ivermectin.
You meant to type mG, right? MG would be 'MegaGram'.
 
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