If one wants to stick with strictly bookshelf systems, you really need to be careful with subwoofer choices.
I would not suggest the PB-10 with the Axioms M-22's, as they just are not a good match. The 22's need a subwoofer with a 100 Hz linear response, IMO.
Both the M22's and 170 SE's compare well with the Paradigm Studio 20 V.3's ... The 170's are a more natural competitor, where the M22's, crossed at 100 Hz, are capable of higher SPL's than either the Ascends or the Paradigms.
The 170's/340's work great with the Hsu VTF-3 Mark II, and, again IMO, pairing speaker of that quality with the SVS does the speakers is disservice.
I would rather have 170's, and put the $$$$ into the VTF-3 Mark II.
SO ... for two systems from each company ?
Ascend ...
4 x 170 + 1 x 340 SE + a VTF-3 Mark II. This is $1698 delivered.
Axiom ...
2 x M22 + 2 x QS8 + 1 x VP-150 + 1 x EP-350. This is $1957 delivered.
The EP-350 can take the 100 Hz crossover. The Ascend/Hsu combo is fantastic, as is the Axiom rig. The Axiom will play louder, and has the Quadrapole surround - but it is $260 more money, too.
However, even though this was not asked - if I was to pick my favorite system from Axiom for the $$$ ... and was sticking to bookshelf speakers, it would be ...
4 x M3's + 1 x VP-150 + 1 EP-500.
$1900 delivered ... and true 20 to 20,000 Hz performance, and a totally seemless sound.
AND... for the Ascend package, I would upgrade the VTF-3 Mark II to the VTF-3 HO ... it is a VERY close match to the EP-500 ... again, for about $1900 delivered for 4 x 170's, 1 x 340 SE, and the VTF-3 HO.
Those two packages will make a guy happy for YEARS.
Is everyone sufficiently confused now ?