The job of an amplifier, for example, is to linearly amplify the signal. This is easily accomplished. No coloration(s) induced by the amplifier. Perceptual reasearch exists for every parameter of performance(harmonic distortion audiblity, signal to noise ratio, frequency response, etc.) that will cause audible difference(s). The amplifier should not, at any time, rise above the known audible thresholds during normal operation/use. For sound signature modification, it is most beneficial to use auxillary devices that can modify the factors in a controlled manner. You can then tune the sound to exactly what you prefer, instead of relying on the random changes that are introduced by non-linear amplification devices, that can not be controlled. I believe I have recommended such products to you in the past, in different threads.
-Chris