Not much activity on this game anymore, but I've been playing it on the PC for awhile now. I've tried both male and female Shepards. I'm on the 6th time through as a veteran Adept and am finding it challenging enough that I'll probably put a cap on it there. Slept with everybody but Garrus and Morinth, good guy, bad guy, neutral guy and I'm still finding stuff that changes with each playthrough depending on when you recruit, when you do the loyalty missions, etc. It's a very enjoyable experience. Great voice acting and character customization (create your face/looks) that really match well.
Kudos to Bioware.