I think we need more info here as to what you mean?
A fiberglass enclosure is fine for sub drivers as the resonance points are generally well above the pass band of the driver. However unless you build a constraint layer type enclosure with the fiberglass you will have lots of mid-range/mid-bass cabinet resonance issues.
I built many solidly constructed enclosures for vehicles (kick panels, etc,) out of fiberglass and they almost always had resonance problems. Though in a vehicle they are much less noticeable.
Also fiberglass builds in rigidity the more bends and curves you can put into it. The straighter/flatter it becomes, the weaker it becomes. On a flat surface you will need many layers to equal MDF. It would need to be close to 1/2" thick or more and that assumes you add in some sort of density increasing agent to the resin such as a fine sand, etc.