So, be prepared to line it with something soft and flexible that can stay put. How about modeling clay or plasticine?
How large a woofer are you planing to mount? With a sphere as large as you describe, it might have to be thicker to avoid flexing from the backwave of a large woofer.
I'm completely flexable on what's inside the sphere, including deforming the interior out of sphere shape as needed.
Do not use steel, as it will interact with the speaker magnet and the inductor coils of any crossover. Some types of stainless steel are not magnetic, but they will cost more. Aluminum might be OK, but you should check that first to see how a large sphere of aluminum would affect a speaker's magnet and voice coil.
I'm planning on an external crossover (or, if I was going to use a passive crossover, I'd put it in the woofer box which will be MDF).
The steel in the basket doesn't interfere, nor do the actual magnets in other drivers when drivers are placed on top of each other. Would it really be a problem as long as the sphere was at least twice the length of the driver with magnet in diameter?
On the other hand: there should eventually be a tweeter that will be mounted to the top of top-of-the-front of the outside of the sphere: that would be right next to the metal. Perhaps I do need to consider a different material that can be made to look like brushed steel (such as aluminum).
As to mounting: it would be sphere on mounting on woofer box. The woofer box will actually be my first project as soon as funding permits (a long time sadly), the mid and upper the second (assuming the first goes well). I'm hoping the bass unit will be rather inert (assuming I build correctly), and I can do some isolation in the connecting materials.
It's a bit of a thought exercise right now. My next real task is to get my speakers from Chris. I'll learn a lot more about external crossovers then when I'm staring at a pair; as well as more about how very well braced cabinets behave in reality. Can't wait !