Well, I see your preference is on watching movies. I also have a bit better idea of how big your room is. What is the height of your listening area? This will give us the total cubic ft. Does your room open up to other areas or is it more confined? Generally speaking, (2) subs when placed together will yield a 6db gain in output. When placed apart, (2) subs will result in a smoother sound thus spreading the bass around the room more evenly. Since you play your stuff loud, I would have to say that (2) 10" subs will play louder if you can co-locate them. If, on the other hand, you have to place them apart my vote then would go to the 12" sub.
As far as Axiom speakers go, from what I have heard lets say I am real impressed. What is more important, is how YOU feel about them. After all, who knows better than YOU about what YOU like right? My guess is that you would be quite happy. I must say, though, that I am not all that familiar with that sub. The EP500 is stellar and packs quite a punch. Keep in mind too, that I am by no means an expert. There are others here who can offer some very good useful advice. Demo all the speakers you can-that way you can make a well informed decision as well as be happy with YOUR decision. Hope this helps. Welcome to the forum.