Floyd E. Toole is the acknowledged leader in scientific testing of listener preferences in audio sound, especially as it applies to speakers. He had this interesting comment on audiophiles and the great debate:
"Knowledge of the products that are being evaluated by subjective testing is generally understood to be a powerful source of psychological bias. In scientific tests of many kinds of human perception, even wine tasting, considerable effort is expended to hide the identity of the devices or substances being subjectively evaluated. In audio, though, things are more relaxed, and otherwise serious people persist in the belief that they are immune to such factors as price, size, brand, etc. In some of the "great debate" issues, such as whether amplifiers, wires, and the like have an audible effect, there are those who claim that disguising the product identity actually prevents listeners from hearing differences that are in the range of extremely small to inaudible. This debate shows no signs of slowing down."