I say yes. But I have not heard both types of systems you describe.
I can't really give a specific example [not much high-end brand experience], but I'm thinking like high end bookshelves with tweeter + woofer vs floorstanders with multiple drivers [same price range of course].
Edit; Maybe I do have an example
Infinity Beta 50 [~$800/pr]
vs
RBH MC-6C [~$850/pr]
Perhaps the RBH's sound better? I definitely think it's possible.