Congrats!
1....ideally I've found the side surrounds perform best on the side of the viewer and slightly behind. The far back wall positions I would probably scrap those.
2....your space is slightly more than 5000 cu ft...there are single subs that can pressurize your space.
One vs two in your case is mostly about balance, eliminating dead spots....I would go with 2 subs.
3....do it
4....For your LCR speakers...go inwall vs in ceiling...yeah, a back box design can have higher performance...especially bass, but sound bleed might be more of an issue with the Atmos or in ceiling speakers.
5.... HSU, Rythmik, SVS, Seaton, etc., if it were me I'd just look for the best "pair" deal among those brands. I found it was hard to beat the price/performance of the HSU subs, but that was a yr ago.