I don't think Aluminum is a good material for a speaker. Nothing has been shown to be superior to wood or MDF.
Aluminum has a Young's modulus and rings.
Studies have shown Birch plywood to have the best damping in the mid range frequencies and MDF to be superior in the lowest frequencies.
As to design you start with the speakers. Enclosure design will depend on the type of loading selected and the T/S parameters of the driver. You never start with the cabinet!
I would not advise using entirely JBL drivers. They are not known for high performance midrange drivers for a start.
This new and excellent midrange/HF horn I don't think is available for DIY.
There are very few good midrange drivers. I would advise starting with a two way. In a two way there is little advantage over an active versus passive crossover in a domestic speaker. For three ways there are significant advantages to to active designs. The design must be custom and probably the easiest way to accomplish this is with mini DSP.
Finally it is beyond the scope of a forum like this to teach you how to design a complete speakers if you have no experience or body of dedicated study. It is much more complex than you think.