then the next option is a benadryl, my male used to get very nervous when taking him for trips longer than 15 or 20 minutes, we would stop and let him run off some energy and then he wouldnt want to get back in the car, he would cry and fight then be impossible to control once in the car. He was fine initially getting in, but after 15-20 minutes he would start flipping out... So my vet said to give him benadryl tablets 30 minutes prior, and vawalah, problem solved, I could drive to mexico with out stopping and he would be fine...