I don't even like Audyssey. So no, it isn't absolutely necessary in my view.
The more important question is whether or not to use room calibration at all. The answer to that, of course, lies in the acoustics of your room and neither you nor I know what that is in your case. So without getting into a long drawn out discussion let me simply suggest you spend some time listening to your system with it and without it. Whichever sounds best to you will be the way to go.
That's exactly what Denon dealers told me today: Trust your ears.
Also, they have never use Audyssey calibration on AVRs in their show room to achieve best possible sound!?
For me, sound on my Denon is perfect, my only dilemma is why Audyssey measurement can’t finish speaker setup and be able to compare sound “with or without Audyssey”.
They said “it's probably something trivial”. Like, central speaker is deeper in the shelf than it should be or front speakers are too close to the window or wall,
living room door blocking rear speaker, etc…
Maybe I should go to the store with my receiver and let them do the measurement just to be sure that is nothing wrong with my Audyssey.
At the end, they told me
that if I am satisfied with sound that I have achieved -than I should just forget process of automatic calibration.