I have a RTI T3-V, and it is pretty cool. I use it to control my lighting (Lutron HomeWorks) and a portion of my home theater. My amps and so forth don't have 12v triggers, but it works well for controlling everything else.
Programming wasn't bad, certainly easier than a Crestron... I've messed with Crestron systems in a few applications and find them very cumbersome: hard to program, software running on the devices runs on Windows and gets the blue screen of death, for a while they had battery issues in their bigger touchscreens, they are too expensive and don't offer much over less expensive versions. Their new mid-sized panel looks like crap, so you really have to go to the top of the line one, and thats super expensive. Battery life is better but not great, and they are brick heavy. Then their wall unit looks like something out of a old sci-fi movie.
The thing with universal remotes, is that without feedback, don't program macros. If something gets changed without the remote, it has no idea, and it just becomes more of a pain than it is worth. Keep the programming simple, just another version of your remotes in one box. For my processor I keep the volume, shortcuts to my main inputs, and my most often used modes (Pure Direct Stereo and THX). Don't program "Watch a Movie" ... if it misses one fire it'll just get confused. Doesn't matter which one you use, in my experience, they all get confused doing that eventually.